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• Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.
  This study showed that telmisartan (80 mg/day) did not reduce insulin resistance in HIV-positive people taking antiretroviral drugs
• Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.
  In this large trial, although tranexamic acid was safe, there was no significant difference in functional status 90 days after intracerebral haemorrhage.
• Information Infrastructures within European Health Care: Working with the Installed Base [Internet].
  This open access book consolidates experiences from across Europe on the design, development, implementation and evolution of inter-organisational information infrastructures for healthcare. It provides insights with practical relevance for those involved or interested in the planning and implementation of such infrastructures and includes 11 empirical cases on the introduction of core infrastructural arrangements in different […]
• Peer Review, Peer Education, and Modeling in the Practice of Clinical Ethics Consultation: The Zadeh Project [Internet].
  This open access book about the Zadeh Project demonstrates and explores a core question in clinical ethics: how can ethics consultants be accountable in the face of a robust plurality of ethical standpoints, especially those that underwrite practices and methods for doing ethics consultation as well as those viewpoints and values encountered in daily clinical […]
• The South Texas Health Status Review: A Health Disparities Roadmap [Internet].
  As America's most populous state goes, so goes the nation. And within that state, the 38 counties comprising South Texas--a highly populated, largely Hispanic area characterized by high uninsured rates and low numbers of health care providers--are emblematic of nationwide crises in public health. The South Texas Health Status Review: A Health Disparities Roadmap brings […]
• Handbook of Life Course Health Development [Internet].
  This open access handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous […]
• Nicotinic Acetylcholine Receptor Signaling in Neuroprotection [Internet].
  This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection […]
• Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands [Internet].
  The subject of this open access book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular […]
• mHealth Innovation in Asia: Grassroots Challenges and Practical Interventions [Internet].
  This open access book offers a detailed account of a range of mHealth initiatives across South, Southeast and East Asia. It provides readers with deep insights into the challenges such initiatives face on the ground, and a view of the diverse cultural contexts shaping strategies for overcoming these challenges. The book brings together various discussions […]
• Evaluating Evidence of Mechanisms in Medicine: Principles and Procedures [Internet].
  This open access book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence […]