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• Healthy Aging in Action: Advancing the National Prevention Strategy [Internet].
  In 2011, the year the National Prevention Strategy was released, the first wave of the baby boomer generation celebrated its 65th birthday. Since then, the number of individuals over the age of 65 has reached 46 million and is projected to reach 74 million by 2030. Americans reaching the age of 65 today can also […]
• Clinical Review Report: tiotropium bromide monohydrate and olodaterol hydrochloride (Inspiolto Respimat) for oral inhalation [Internet].
  The objective of this review is to evaluate the beneficial and harmful effects of Tiotropium bromide monohydrate plus olodaterol hydrochloride (TIO/OLO) for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
• Functional Magnetic Resonance Imaging (fMRI): An Invaluable Tool in Translational Neuroscience [Internet].
  The sophisticated methods of neuroscience—including molecular genetics, structural and functional neuroimaging, animal models, and experimental tasks that approximate real-world behaviors in human research—have yielded important insights about typical functioning and neurobehavioral disorders. Translational neuroscience endeavors to use this knowledge to improve the human condition by developing and improving interventions for these disorders. This paper reviews […]
• Pharmacoeconomic Review Report: Ticagrelor (Brilinta) [Internet].
  Ticagrelor is an oral, direct-acting, selective and reversibly binding P2Y12 receptor antagonist that prevents adenosine diphosphate (ADP)-mediated P2Y12-dependent platelet activation and aggregation. The proposed new indication is ticagrelor, combined with low-dose (75 mg to 150 mg) acetylsalicylic acid (ASA), for the secondary prevention of atherothrombotic events in adult patients with a history of myocardial infarction […]
• CADTH Canadian Drug Expert Committee Final Recommendation: Tesamorelin: (Egrifta — Theratechnologies Inc.): Indication: HIV-associated lipohypertrophy [Internet].
• Pharmacoeconomic Review Report: Tesamorelin (Egrifta) [Internet].
  Tesamorelin (Egrifta) is indicated for the treatment of excess visceral adipose tissue (VAT), as assessed by waist circumference ≥ 95 cm for males and ≥ 94 cm for females, and confirmed by a VAT level > 130 cm2 by computed tomography (CT) scan, in treatment-experienced adult HIV-infected patients with lipodystrophy. The dosage is 2 mg […]
• CADTH Canadian Drug Expert Committee Final Recommendation: Ticagrelor: (Brilinta — AstraZeneca Canada Inc.): Indication: Secondary Prevention of Atherothrombotic Events [Internet].
• Bobath Therapy for Patients with Neurological Conditions: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet].
  This report expands upon a previously completed summary of abstracts report. The objective of the current report is to summarize the evidence regarding the clinical effectiveness and cost-effectiveness of Bobath therapy for treatment of patients with neurological conditions as well as to summarize evidence-based guidelines.
• Inner Speech: New Voices.
• Use of Secondary Population-Based Databases to Evaluate the Safety of Medications [Internet].
  Public concern is increasing over the safety of medicines, particularly serious adverse events detected after extensive use of products in the general marketplace. This concern has led to the need for prompt evaluation of safety signals within large populations following drug approval. The most relevant and available data resources primarily include electronic health care claims […]